Abstract:The joint effects of illumination ,salinity and pH on filtration rate of juvenile razor clam Solen grandis were studied using Box‐Behnken experimental design and response surface methodology ( RSM ) under laboratory conditions ,aiming to quantifying the relationship between the filtration rate and the a‐bove three factors ,and to the optimal factor combination through statistical optimization approach .The re‐sults showed that there were significant interaction effects between illumination and salinity ,and between illumination and pH on the filtration rate of razor clam juveniles (P<0 .05) .The multivariate non‐linear model is described as y =1 .62+0 .084A+0 .04B -0 .14C -0 .38A2 -0 .65B2 -0 .68C2 (r2 =0 .9821) ,the optimal conditions for filtration were found under conditions of illumination of 1109 .17 lx ,salinity of 25 .12 and pH=7 .89 .T he findings indicate that the proposed model is reasonably accurate and can be used for describing and predicting the grow th features of juvenile razor clam in different environmental factors .