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| Comparative Bacteriostasis of Oxolinic Acid and Norfloxcin against Pathogenic Bacterium Aeromonas hydrophila in Allogyogenetics Silver Crucian Carp Carassius auratus gobelio |
| SUN Penghui,LU Jianfei,QIU Weichen,L Liqun |
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Abstract In vitro and in vivo pharmacokinetics of oxolinic acid and norfloxcin against pathogenic bacteri‐um Aeromonas hydrophila (AH10) were studied in allogyogenetics silver crucian carp Carassius auratus gobelio with body weight of 150—200 g singly and orally administrated at a dose of 20 ,30 ,and 40 mg per kg body weight at water temperature of (25 ± 2) ℃ .The minimal inhibitory concentration (MIC) on AH10 was shown to be 1μg/mL in oxolinic acid and 0 .5μg/mL in norfloxcin .The maximum serum concentration of oxolinic acid in allogyogenetics silver crucian carp was 4 .1 μg/mL at a dose of 20 mg per kg body weight ,6 .0 μg/mL at a dose of 30 mg per kg body weight ,and 8 .89μg/mL at a dose of 40 mg per kg body weight ,and the maximum serum concentration of norfloxcin were 11 .5 μg/mL at a dose of 20 mg per kg body weight ,15 .1 μg/mL at a dose of 30 mg per kg body weight ,and 18 .9 μg/mL at a dose of 40 mg per kg body weight .Cmax of oxolinic acid /MIC of oxolinic acid was 4 .1 ,6 .0 and 8 .89 at various doses ,respec‐tively ;Cmax of norfloxcin /MIC of norfloxcin was 23 ,30 .2 and 37 .8 at various doses ,respectively .The ar‐ea under the curve (AUC24 ,0—24 h) of oxolinic acid/MIC of oxolinic acid was 21 .6214 ,33 .1449 and 39 .1846 at various doses ,respectively ;AUC24 of norfloxcin /MIC of norfloxcin was 274 .75 ,451 .55 and 578 .35 at various doses ,respectively .Based on the AUC24/MIC and Cmax/MIC ,there was greater bacteri‐ostasis in norfloxcin than in oxolinic acid against A .hydrophila in allogyogenetics silver crucian carp .
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Received: 25 March 2016
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