Abstract：The trimethoprim(TMP)levels were analyzed in the muscle, blood, kidney and liver of Japanese flounder Paralichthys olivaceus orally administrated by reversed-phase high performance liquid chromatography and 3P87 softward to study the pharmacokinetics of TMP in the fish. The results showed a two-compartment open model best fitted the data in the four tissues. The major pharmacokinetic parameters in muscle, blood, kidney and liver were as follows,respectively:Time when maxium concentration(t_(max)max)was obtained were 18.72 h, 12.94 h, 23.13 h and 19.49 h; maximum concentration(C_(max))were 13.80 μg/ml, 18.23 μg/ml, 32.79 μg/ml and 27.40 μg/ml;elimination half-life(t_((1/2)β))were 23.64 h, 21.47 h, 16.72 h and 15.99 h, indicating that the assimilation and elimination of TMP was slower, that the level in blood was higher and that the maintaining time was longer in Japanese flounder.
收稿日期: 2010-01-25
引用本文:
盖春蕾,朱安成,李天保,叶海斌,许拉,王勇强. 甲氧苄氨嘧啶在牙鲆体内的药代动力学研究[J]. , 2010, 29(1): 15-18.
GAI Chun-lei,ZHU An-cheng,LI Tian-bao,YE Hai-bin,XU La,WANG Yong-qiang. Pharmacokinetics of Trimethoprim in Japanese Flounder(Paralichthys olivaceus). , 2010, 29(1): 15-18.
