Abstract：Razor clam polysaccharide with various biological activity was rich in polysaccharide functional product. Establishment of more economical and reasonable experimental design through maths model,it was very important signification for exploitation and application of razor clam polysaccharide. The research carried out in the Qinhangdao sea showed that the supersonic assistance enzymolysis extraction was found to be the preferable polysaccharide extraction method for the razor clam polysaccharide extraction by the response surface method. The results indicated that the feasible extraction condition was as the following: 30 min of supersonic assistance extract time was,amount of papain of 3.99%,extract Temperature of 50.9 ℃,extract time of 8.94 h. Under this condition the razor clam polysaccharide extraction content was achieved at a rate of the 9.41 mg/g fresh weight. This research has the vital significance regarding the marine shellfish polysaccharide function product raw material selection and the product development and the application.
