Effects of Enrofloxacin on Transaminase Activity in Serum and Liver of Siberian Sturgeon Acipenser baeri
LIU Pan, YANG Mu, JIA Chengxia, ZHANG Qingjing, QU Jiangqi
Fishery Resources and Environment Observation and Experimental Station in Northern China, Ministry of Agriculture and Rural Affairs, Beijing Key Laboratory of Fishery Biotechnology, Beijing Fisheries Research Institute, Beijing 100068, China
Abstract：Enrofloxacin was orally administered to Siberian sturgeon Acipenser baeri at 15 ℃ and 26 ℃, respectively. The changes in glutamic-oxalacetic transaminase(GOT) and glumtaic-pyruvic transaminase(GPT) activities were measured with time in serum and liver tissues at 0.125 h, 0.25 h, 0.5 h, 1.0 h, 1.5 h, 2 h, 4 h, 6 h, 8 h, 12 h, 18 h, 24 h, 36 h, 48 h, 60 h, 72 h, 96 h and 120 h after administration. The results showed that the activities of GOT and GPT were increased at two temperatures. At 15 ℃, the activity of GOT was significantly higher in serum than that in liver within 6—24 h; at 36—120 h(except 72 h), the activity of GOTwas significantly higher in liver than that in serum. GPT activity was significantly higher in liver than that in serum in 0.25—4 h, and was significantly higher in liver than that in serum in 36—120 h. At 26 ℃, the activity of GOTwas significantly higher in serumthan that in liver within 6—120 h; at 0—0.5 h, the activity of GPTwas significantly higher in serumthan that in liver, while from 1.5—120 h, the activity of GPTwas significantly higherin liver than that in serum. It was found that after oral administration of enrofloxacin, the activities of transaminases (GOT and GPT) in serum and liver were gradually increased to a certain extent, then slowly decreased and remained stable. However, the content of GOTwas significantly higherin serum in 18—36 h at 26 ℃ than that in liver, indicating that liver cells had been damaged to a certain extent. The enrofloxacin had no significant toxic effect on the serum and liver of Siberian sturgeon at the appropriate temperature and 10 mg/kg body weight. The findings provide theoretical basis for the rational use of enrofloxacin in the breeding of Siberian sturgeon.
2022, Vol. 41 
